Related Experiment Video
Updated: Jul 4, 2025
03:29
Author Spotlight: Advancing Therapeutics to Treat Vibriosis in Humans and Aquatic Organisms
Published on: May 31, 2024
463
A novel isatin Schiff based cerium complex: synthesis, characterization, antimicrobial activity and molecular docking
Heba E Saad1, Gaber M Abu El-Reash2, Mohamed Gaber1
1Department of Chemistry, Faculty of Science, Tanta University, Tanta, 31527, Egypt.
BMC Genomics
|February 8, 2024
Summary
A novel cerium (III)-Schiff base complex was synthesized and characterized. This complex demonstrated enhanced antimicrobial activity compared to its ligand, showing promise for new therapeutic agents.
Area of Science:
- Coordination Chemistry
- Materials Science
- Antimicrobial Research
Background:
- Schiff bases derived from isatin and thiadiazole derivatives are known for their diverse biological activities.
- Cerium complexes are explored for their potential therapeutic applications, including antimicrobial properties.
Purpose of the Study:
- To synthesize and characterize a novel isatin-Schiff base ligand (L2) and its cerium (III) complex (C2).
- To evaluate the antimicrobial and antifungal potential of the synthesized compounds.
- To investigate the binding affinity of the ligand and complex with a fungal protein using molecular docking.
Main Methods:
- Synthesis of isatin-Schiff base ligand (L2) via reaction of isatin and 2-amino-5-methylthio-1,3,4-thiadiazole.
- Hydrothermal synthesis of cerium (III)-Schiff base complex (C2).
- Characterization using spectroscopic techniques (FT-IR, NMR, UV-vis, Mass Spectra), elemental analysis, TGA, HR-TEM, and FE-SEM/EDX.
- In vitro antimicrobial activity testing against various microorganisms.
- Molecular docking simulations using MOE software to assess protein-ligand interactions.
Main Results:
- The novel Schiff base ligand (L2) and its cerium (III) complex (C2) were successfully synthesized and fully characterized.
- Molecular docking simulations indicated a stronger binding affinity of the cerium complex (C2) to the Avr2 effector protein of *Fusarium oxysporum* compared to the ligand (L2).
- In vitro studies revealed that the cerium (III)-Schiff base complex (C2) exhibited superior antimicrobial and antifungal activity than the free ligand (L2).
Conclusions:
- The synthesized cerium (III)-Schiff base complex represents a promising candidate for developing new antimicrobial agents.
- The enhanced biological activity of the complex is attributed to the presence of the cerium ion and the Schiff base structure.
- Further research into the therapeutic potential of this complex is warranted.
Keywords:
Antimicrobial activityCerium (III)-Schiff base complex C2Isatin-Schiff base L2Molecular operating environment (MOE)TGA and hydrothermal reactionMore Related Videos
Related Concept Videos
02:52Stereoisomerism
11.9K
Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula.
Transition metal complexes often exist as geometric isomers, in which the same atoms are connected through the same types of bonds but with differences in their orientation in space. Coordination complexes with two different ligands in the cis and trans positions from a ligand of interest form isomers. For example, the octahedral [Co(NH3)4Cl2]+ ion has two isomers (Figure 1) In the cis...
Isomers are different chemical species that have the same chemical formula.
Transition metal complexes often exist as geometric isomers, in which the same atoms are connected through the same types of bonds but with differences in their orientation in space. Coordination complexes with two different ligands in the cis and trans positions from a ligand of interest form isomers. For example, the octahedral [Co(NH3)4Cl2]+ ion has two isomers (Figure 1) In the cis...
11.9K
02:34Structural Isomerism
19.2K
Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can...
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can...
19.2K