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Tropheryma whipplei Endocarditis Presenting as Valvulopathy and Multiple Septic Emboli
Ralph Akiki1, Nazli Begum Ozturk2, Reenal Patel3
1Department of Internal Medicine, Corewell Health William Beaumont University Hospital, Royal Oak, MI, USA. ralphakiki7@gmail.com.
Journal of General Internal Medicine
|February 9, 2024
Summary
Culture-negative endocarditis requires a high suspicion, especially when blood cultures are negative. A positive blood polymerase chain reaction (PCR) test for Tropheryma whipplei confirmed rare endocarditis, necessitating prompt treatment.
Area of Science:
- Infectious Diseases
- Cardiology
- Microbiology
Background:
- Culture-negative endocarditis presents a diagnostic challenge, often requiring advanced molecular techniques.
- Septic emboli and large vegetations are critical indicators of infective endocarditis, even with negative blood cultures.

