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Transplantation and Cellular Therapy for Older Adults-The MSK Approach
Richard J Lin1,2, Parastoo B Dahi3, Beatriz Korc-Grodzicki4
1Adult Blood and Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA. linr@mskcc.org.
Current Hematologic Malignancy Reports
|February 9, 2024
Summary
Older adults can benefit from hematopoietic cell transplantation and cellular immunotherapy for blood cancers. Geriatric assessment helps optimize treatment selection and outcomes for elderly patients.
Area of Science:
- Oncology
- Hematology
- Geriatrics
Background:
- Hematologic malignancies disproportionately affect older adults, often presenting as advanced disease.
- Hematopoietic cell transplantation (allogeneic and autologous) and cellular immunotherapies offer curative potential for blood cancers.
- Older patients face challenges in accessing and undergoing these intensive treatments due to unique health considerations.
Purpose of the Study:
- To review the benefits and improving outcomes of transplantation and cellular therapy in older adults with hematologic malignancies.
- To highlight the role of geriatric assessment in selecting and optimizing older patients for these treatments.
- To present an institutional approach and early results for older adults undergoing these therapies.
Main Methods:
- Review of current evidence on hematopoietic cell transplantation and cellular immunotherapy in older adults.
- Emphasis on the application of geriatric assessment tools for patient selection and management.
- Description of a specific institutional protocol and its preliminary outcomes.
Main Results:
- Evidence supports the efficacy and improving outcomes of transplantation and cellular therapy in older adults.
- Geriatric assessment facilitates appropriate patient selection and optimization for treatment.
- Early results from the described institutional approach show encouraging outcomes.
Conclusions:
- Hematopoietic cell transplantation and cellular immunotherapy are viable options for older adults with hematologic malignancies.
- Geriatric assessment is crucial for maximizing the benefits and minimizing risks in this population.
- Optimized treatment strategies can improve access and outcomes for older patients.
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