Exploring Alzheimer's disease: a comprehensive brain connectome-based survey

Area of Science:

• Neuroscience
• Neurology
• Medical Research

Background:

• Dementia, particularly Alzheimer's disease (AD), is a growing global health concern.
• Pathological protein accumulation in AD disrupts specific brain regions and their interconnected networks.
• The brain connectome concept aids in understanding brain complexity and disease mechanisms.

Purpose of the Study:

• To systematically review brain network research in Alzheimer's disease.
• To critically evaluate existing methodologies for studying brain networks in AD.
• To provide insights and perspectives for future Alzheimer's disease research.

Main Methods:

• Systematic literature review of studies on brain networks and AD.
• Critical analysis of methodologies used in connectome research for AD.
• Synthesis of current knowledge and identification of research gaps.

Main Results:

• Brain networks are pivotal in AD development and progression.
• Connectome research offers potential for elucidating AD mechanisms.
• Existing methodologies have limitations that require further investigation.

Conclusions:

• Further research into the brain connectome is essential for understanding AD.
• Methodological advancements are needed for robust AD connectome studies.
• This review provides a foundation for future research directions in AD neurodegeneration and network analysis.