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Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods
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Monte Carlo Optimization Method Based QSAR Modeling of Placental Barrier Permeability

Predrag Vukomanović1,2, Milan Stefanović1,2, Jelena Milošević Stevanović1,2

  • 1Faculty of Medicine, University of Niš, Niš, Serbia.

Pharmaceutical Research
|February 10, 2024
PubMed
Summary

Quantitative structure-activity relationship (QSAR) models can predict drug placental transfer, offering a faster, cheaper alternative to in vitro perfusion. This study developed a robust QSAR model for high-throughput screening of drug placental permeability.

Keywords:
Monte Carlo optimization: SMILESQSARmolecular modelingplacental barrier permeability

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