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Influence of the HLA-Cw6 Allele and IFIH1/MDA5 Gene Variants on the Cardiometabolic Risk Profile of Patients with

Rubén Queiro1,2,3, Ignacio Braña1, Estefanía Pardo1

  • 1Rheumatology Division, Hospital Universitario Central de Asturias (HUCA), 33011 Oviedo, Spain.

Journal of Clinical Medicine
|February 10, 2024
PubMed

Insights

The HLA-Cw6 allele in psoriasis patients did not directly improve cardiometabolic health. Its apparent benefits on cardiovascular risk factors were explained by other patient characteristics, not the allele itself.

Area of Science:

  • Immunodermatology
  • Cardiology
  • Genetics

Background:

  • Cardiovascular comorbidity is prevalent in psoriasis and psoriatic arthritis (PsA).
  • A potential link between HLA-Cw6 allele and improved cardiometabolic profile in these patients has been suggested.
  • This study aimed to validate this association in a distinct patient cohort.

Purpose of the Study:

  • To investigate the association between the HLA-Cw6 allele and cardiometabolic risk factors in patients with psoriasis and PsA.
  • To determine if the HLA-Cw6 allele influences cardiometabolic health independently of other clinical factors.
  • To explore the role of IFIH1/MDA5 gene variants in relation to PsA and cardiometabolic risk.

Main Methods:

  • A cross-sectional observational study of 572 psoriasis patients (30% with PsA).
  • Collection of detailed clinical variables and cardiometabolic risk factors.
  • Genotyping for HLA-Cw6 allele and IFIH1/MDA5 gene variants (rs1990760).
  • Analysis using linear and logistic regression models to assess associations.

Main Results:

  • HLA-Cw6 was confirmed to be associated with type I psoriasis.
  • HLA-Cw6 was found to be protective against PsA (OR: 0.65).
  • Initially, HLA-Cw6 carriers showed lower waist perimeter, BMI, and reduced risk of hypertension and diabetes, but these associations disappeared after adjusting for other factors.
  • No IFIH1/MDA5 gene variant was linked to cardiometabolic risk factors.

Conclusions:

  • The apparent protective effect of HLA-Cw6 on the cardiometabolic profile in psoriatic patients is likely mediated by other factors such as age, sex, disease duration, or presence of arthritis.
  • The HLA-Cw6 biomarker itself may not be an independent predictor of cardiometabolic risk in this population.
Abstract

Keywords:
HLA-Cw6IFIH1/MDA5 genecardiovascular riskpsoriasispsoriatic arthritis

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