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Exploring the Potential of Bioactive Peptides: From Natural Sources to Therapeutics
Kruttika Purohit1,2, Narsimha Reddy2,3, Anwar Sunna1,2,4
1School of Natural Sciences, Macquarie University, Sydney, NSW 2109, Australia.
International Journal of Molecular Sciences
|February 10, 2024
Summary
This review explores bioactive peptides, protein fragments with health benefits, detailing their discovery, extraction, and analysis. It highlights their therapeutic potential in drug development due to unique advantages.
Area of Science:
- Biochemistry and Pharmacology
- Peptide Science
Background:
- Bioactive peptides offer therapeutic advantages like enhanced penetration and low toxicity.
- Their potential in drug development is increasingly recognized.
Purpose of the Study:
- To provide a comprehensive review of bioactive peptide science.
- To cover peptide discovery, extraction, characterization, and bioactivity assessment.
Main Methods:
- Peptidomic exploration of natural sources.
- Extraction techniques: enzymatic hydrolysis, microbial fermentation, specialized methods.
- Mass spectrometry (LC-MS, CE-MS) and bioinformatics for identification.
- Bioactivity assessment: in vitro, in silico, phage display, cell-based assays.
Main Results:
- Detailed overview of methods for peptide discovery and extraction.
- Comprehensive outline of mass spectrometry and bioinformatics tools.
- Exploration of methodologies for assessing peptide bioactivity.
- Discussion of structure-activity relationships for AMPs, ACEs, and AOPs.
Conclusions:
- Bioactive peptides represent a promising area for therapeutic applications.
- Further research directions are identified for peptide science and drug development.
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