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Edaravone: A Novel Possible Drug for Cancer Treatment?

Elisa Duranti1, Nicoletta Cordani1, Chiara Villa1

  • 1School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.

International Journal of Molecular Sciences
|February 10, 2024
PubMed

Insights

Edaravone, an antioxidant and anti-inflammatory drug, shows promise in cancer therapy. This review explores its potential as an antitumor agent and its role in reducing side effects from conventional cancer treatments.

Area of Science:

  • Oncology
  • Pharmacology
  • Drug Repurposing

Background:

  • Cancer remains a leading global cause of death despite advances in understanding tumor biology.
  • Drug repurposing is an emerging strategy in cancer therapy, focusing on existing medications.
  • Edaravone, approved for cerebral infarction and ALS, possesses antioxidant and anti-inflammatory properties.

Purpose of the Study:

  • To review the diverse applications of edaravone in cancer treatment.
  • To evaluate edaravone's potential as a standalone or combination antitumor drug.
  • To assess edaravone's efficacy in mitigating side effects of conventional cancer therapies.

Main Methods:

  • Comprehensive literature review of studies on edaravone in cancer therapy.
  • Analysis of edaravone's pharmacological properties relevant to oncology.
  • Examination of preclinical and clinical data regarding edaravone's antitumor and cytoprotective effects.

Main Results:

  • Edaravone exhibits anti-proliferative and cytoprotective activities against cancer.
  • Evidence suggests potential for edaravone as a monotherapy or in combination regimens.
  • Edaravone demonstrates efficacy in ameliorating side effects associated with chemotherapy and radiotherapy.

Conclusions:

  • Edaravone presents a promising therapeutic candidate for various cancer types.
  • Its dual role as an antitumor agent and supportive therapy warrants further clinical investigation.
  • Edaravone's repurposing offers a novel strategy to improve cancer treatment outcomes and patient quality of life.
Keywords:
canceredaravoneoxidative stress

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