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Related Experiment Video

Updated: Jun 19, 2026

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Rosavin Alleviates LPS-Induced Acute Lung Injure by Modulating the TLR-4/NF-κB/MAPK Singnaling Pathways.

Qiao-Hui Liu1, Ke Zhang1, Shu-Shu Feng1

  • 1Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education, College of Pharmacy, Shihezi University, Shihezi 832002, China.

International Journal of Molecular Sciences
|February 10, 2024
PubMed
Summary

Rosavin, derived from Rhodiola rosea L., demonstrates protective effects against acute lung injury (ALI) by inhibiting key inflammatory pathways. This natural compound shows promise for treating ALI, a condition marked by high mortality.

Keywords:
TLR-4/NF-κB/MAPK pathwayacute lung injuryanti-inflammatorynetwork pharmacologyrosavintranscriptome sequencing

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Area of Science:

  • Pharmacology
  • Immunology
  • Cell Biology

Background:

  • Acute lung injury (ALI) is a severe inflammatory condition with significant morbidity and mortality.
  • Rosavin, a phenylpropanoid glucoside from Rhodiola rosea L., possesses known anti-inflammatory and antioxidant properties.
  • The precise molecular mechanisms and therapeutic potential of rosavin in ALI remain largely unexplored.

Purpose of the Study:

  • To investigate the in vitro anti-inflammatory effects of rosavin on lipopolysaccharide (LPS)-stimulated cells.
  • To evaluate the protective efficacy of rosavin against LPS-induced ALI in a mouse model.
  • To elucidate the molecular mechanisms underlying rosavin's therapeutic actions in ALI.

Main Methods:

  • In vitro studies utilized RAW264.7 and A549 cell lines stimulated with LPS.
  • An in vivo mouse model of ALI was established via LPS injection.
  • Transcriptomics analysis and Western blot assays were employed to examine molecular pathways.

Main Results:

  • Rosavin inhibited the Toll-like receptor 4/nuclear factor-kappa B (TLR-4/NF-κB) signaling pathway in RAW264.7 cells.
  • Rosavin reduced the release of inflammatory factors from LPS-stimulated A549 cells.
  • In vivo, rosavin dose-dependently improved lung histopathology, decreased inflammatory markers, and suppressed TLR-4/NF-κB/MAPK signaling and apoptosis.

Conclusions:

  • Rosavin exhibits significant anti-inflammatory and anti-lung injury effects.
  • The therapeutic benefits of rosavin in ALI are mediated through the inhibition of the TLR-4/NF-κB/MAPK signaling pathway.
  • Rosavin represents a potential therapeutic candidate for managing acute lung injury.