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Obesity

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...

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Updated: Jul 3, 2025

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation

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Published on: April 3, 2017

Neuroinflammation in Obese Children.

Yu G Samoilova¹, M V Matveeva², L V Spirina¹

¹Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.

Bulletin of Experimental Biology and Medicine

|February 10, 2024

Summary

Obese children show increased M2-polarized CD14+CD163+ monocytes, linked to cognitive decline and lower IQ. This suggests a connection between visceral fat, neuroinflammation, and brain function in childhood obesity.

Keywords:

CD163+ monocytes children cognitive impairment neuroinflammation obesity

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Last Updated: Jul 3, 2025

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Isolation of Adipose Tissue Immune Cells

Isolation of Adipose Tissue Immune Cells

Published on: May 22, 2013

Area of Science:

Immunology
Neuroscience
Pediatrics

Background:

Obesity is linked to chronic inflammation and neuroinflammation.
Tissue macrophages in obesity can cross the blood-brain barrier.

Purpose of the Study:

To analyze the association between CD14+CD163+ monocytes and cognitive functions in obese children.
To investigate the role of M2-polarized monocytes in childhood obesity and neuroinflammation.

Main Methods:

Studied 56 obese children and 10 controls.
Assessed body composition and calculated BMI SDS.
Quantified CD14+CD163+ monocytes using flow cytometry.
Evaluated cognitive functions via IQ and Rey test.

Main Results:

Increased M2-polarized CD14+CD163+ monocytes correlated with obesity severity.
Higher monocyte levels were found in children with cognitive decline.
A negative correlation existed between M2 monocytes, IQ, and visceral fat.

Conclusions:

M2-polarized CD14+CD163+ monocytes are associated with obesity and cognitive deficits in children.
Peripheral visceral obesity and neuroinflammation play a role in these findings.