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Author Spotlight: Unveiling the Molecular Basis of Pain Perception and Neuropathic Pain

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Neurotrophic Natural Products.

Yoshiyasu Fukuyama¹, Miwa Kubo², Kenichi Harada²

¹Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, 770-8514, Japan. fukuyama@ph.bunri-u.ac.jp.

Progress in the Chemistry of Organic Natural Products

|February 10, 2024

Summary

Neurotrophins show promise for neurodegenerative disorders but struggle to cross the blood-brain barrier. Small molecule natural products offer a viable alternative, mimicking neurotrophic actions for potential therapeutic development.

Keywords:

Chemical synthesis Natural products Neurite outgrowth Neurogenesis Neuroprotective Neurotrophic activity Neurotrophin Neurotrophin mimetics PC12 cells

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Area of Science:

Neuroscience
Pharmacology
Natural Product Chemistry

Background:

Neurotrophins (NGF, BDNF, NT3, NT4) are crucial for neuronal survival, differentiation, and function, making them potential therapeutics for neurodegenerative diseases.
Clinical trials with neurotrophins have been limited by their inability to cross the blood-brain barrier due to their large protein size.

Purpose of the Study:

To explore small-molecular-weight natural products as alternatives to neurotrophins for treating neurodegenerative disorders.
To review natural products with neurotrophic properties, including neurogenesis, neuritogenesis, and neuroprotection.

Main Methods:

Literature review of natural products with documented neurotrophic activities.
Focus on the chemical structures and biological mechanisms of selected neurotrophic natural products.

Main Results:

Identified various natural products exhibiting neurotrophic effects.
Highlighted the potential of these compounds to stimulate endogenous neurotrophins or enhance neurotrophic signaling pathways.

Conclusions:

Small molecule natural products represent a promising therapeutic avenue for neurodegenerative diseases like Alzheimer's disease.
Further investigation into the chemistry and biology of these natural products could lead to novel treatments.