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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
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During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R...
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Updated: Jul 3, 2025

Comprehensive DNA Methylation Analysis Using a Methyl-CpG-binding Domain Capture-based Method in Chronic Lymphocytic Leukemia Patients
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Long noncoding RNA expression in acute lymphoblastic leukemia: A systematic review.

Sara Cristina Lobo-Alves1, Liana Alves de Oliveira2, Gabriela Canalli Kretzschmar1

  • 1Instituto de Pesquisa Pelé Pequeno Príncipe, Av. Silva Jardim, 1632 - Água Verde, Curitiba, PR 80250-060, Brazil; Faculdades Pequeno Príncipe, Av Iguaçu, 333, Rebouças, Curitiba, PR 80230-020, Brazil; National Science and Technology Institute for Children's Cancer Biology and Pediatric Oncology - INCT BioOncoPed, Porto Alegre, RS 90035-003, Brazil.

Critical Reviews in Oncology/Hematology
|February 10, 2024
PubMed
Summary

Long noncoding RNAs (lncRNAs) show differential expression in Acute Lymphoblastic Leukemia (ALL), with specific lncRNAs like LINC01013 and CRNDE identified as potential biomarkers. Further research and standardized nomenclature are crucial for advancing ALL diagnostics and therapeutics.

Keywords:
Acute lymphoblastic leukemiaCRNDEDifferential gene expressionLINC01013LeukemiaLong noncoding RNANoncoding RNATranscriptome

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A Chromatin Immunoprecipitation Assay to Identify Novel NFAT2 Target Genes in Chronic Lymphocytic Leukemia
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Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Long noncoding RNAs (lncRNAs) are emerging as critical regulators of gene expression.
  • Their role in the pathogenesis of Acute Lymphoblastic Leukemia (ALL) is increasingly recognized.
  • Identifying consistently dysregulated lncRNAs is key to understanding ALL development.

Approach:

  • Systematic literature review of lncRNA expression studies in ALL.
  • Comparative analysis of global expression data for differentially expressed (DE) lncRNAs.
  • Focus on lncRNAs reported in ETV6::RUNX1-positive ALL subtype and general ALL vs. control studies.

Key Points:

  • Four DE lncRNAs (LINC01013, CRNDE, lnc-KLF7-1, LINC01503) were consistently identified across multiple studies.
  • LINC01013, CRNDE, and lnc-KLF7-1 showed concordant expression in ETV6::RUNX1-positive ALL.
  • LINC01503 was consistently downregulated in ALL compared to controls.
  • Twelve additional lncRNAs were DE in more than one RT-qPCR study.

Conclusions:

  • Multiple lncRNAs are consistently reported as differentially expressed in ALL, supporting their potential as biomarkers.
  • These lncRNAs represent promising candidates for therapeutic targets in ALL treatment.
  • Standardization of lncRNA reporting and nomenclature is essential for data verification and compilation.