Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

102
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
102
Chronic Obstructive Pulmonary Disease-I: Introduction01:20

Chronic Obstructive Pulmonary Disease-I: Introduction

2.8K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
2.8K
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

2.8K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
2.8K
Chronic Obstructive Pulmonary Disease01:22

Chronic Obstructive Pulmonary Disease

1.2K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
1.2K
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

2.5K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
2.5K
Stress and Mental Health01:30

Stress and Mental Health

157
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
157

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

NRF2 ameliorates TBI-triggered Parkinsonism: synchronized antioxidant defense and neuroinflammation suppression.

Brain, behavior, and immunity·2026
Same author

<i>Ceropegia gengmaensis</i> (Apocynaceae), a new species from Yunnan, China.

PhytoKeys·2026
Same author

Deep learning generative model for conditional crystal structure prediction of sodium amide.

npj computational materials·2026
Same author

Discovery of a pyrimidine-based steroidal FXR agonist for the treatment of metabolic dysfunction-associated steatotic liver disease.

Bioorganic chemistry·2026
Same author

Development of an efficient recombineering system for Aeromonas.

BMC microbiology·2026
Same author

A Bayesian network meta-analysis of peripheral nerve blocks for postoperative analgesia in adults following hip fracture surgery.

BMC surgery·2026

Related Experiment Video

Updated: Jul 3, 2025

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
06:55

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

22.5K

Assessing causality between chronic obstructive pulmonary disease with depression: A bidirectional Mendelian

Ang Liu1, Ping-Yang Hong2, Bin Su3

  • 1Department of Anesthesiology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, China; Department of Anesthesiology, Heze Municipal Hospital, Heze 274000, China.

Journal of Affective Disorders
|February 10, 2024
PubMed
Summary

This study found no evidence that Chronic Obstructive Pulmonary Disease (COPD) causes depression. However, depression may increase the risk of developing COPD, highlighting the need for integrated care.

Keywords:
Chronic obstructive pulmonary diseaseDepressionMendelian randomization analysis

More Related Videos

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
08:17

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Published on: August 25, 2017

11.0K
Author Spotlight: Establishing a Rodent Model for Investigating Depression Factors in Traditional Mongolian Medicine
05:56

Author Spotlight: Establishing a Rodent Model for Investigating Depression Factors in Traditional Mongolian Medicine

Published on: October 27, 2023

931

Related Experiment Videos

Last Updated: Jul 3, 2025

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
06:55

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

22.5K
Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
08:17

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Published on: August 25, 2017

11.0K
Author Spotlight: Establishing a Rodent Model for Investigating Depression Factors in Traditional Mongolian Medicine
05:56

Author Spotlight: Establishing a Rodent Model for Investigating Depression Factors in Traditional Mongolian Medicine

Published on: October 27, 2023

931

Area of Science:

  • Genetics
  • Epidemiology
  • Psychiatry

Background:

  • The relationship between Chronic Obstructive Pulmonary Disease (COPD) and depression is complex and not fully understood.
  • Existing observational studies suggest potential bidirectional links, but causal inference is challenging.

Purpose of the Study:

  • To investigate the causal relationship between COPD and depression using a two-sample Mendelian randomization approach.
  • To clarify whether COPD increases the risk of depression or vice versa.

Main Methods:

  • Employed a bidirectional Mendelian randomization design.
  • Utilized large-scale genome-wide association study (GWAS) datasets from the UK Biobank, Psychiatric Genomics Consortium, and FinnGen Consortium.
  • Applied various Mendelian analysis methods for robust investigation.

Main Results:

  • No significant causal effect of COPD on the incidence of depression was observed (IVW OR = 0.989, P = 0.824).
  • A significant association was found where depression may increase the risk of developing COPD (IVW OR = 1.421, P = 0.001).
  • This finding was further supported by a second-step analysis (IVW OR = 1.002, P = 0.028).

Conclusions:

  • COPD does not appear to causally increase the risk of depression.
  • Depression may be a risk factor for the development of COPD.
  • Findings emphasize the importance of addressing depression in COPD prevention and management strategies.