Decrease of extracellular fluid in dog submandibular glands during secretion under arterial clamping conditions

Microscopic observations were made of volume changes in ECF of the dog submandibular glands during resting state and stimulated state without blood supply. The interlobular space, one of the compartments of ECF, decreased significantly during stimulation when blood supply was absent. The results show that the interlobular space plays an important role as a reservoir of fluid in salivary secretion.