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The Fibroblast Landscape in Stomach Carcinogenesis
Ela W Contreras-Panta1, Eunyoung Choi1, James R Goldenring2
1Department of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee; Section of Surgical Sciences, Vanderbilt University Medical Center, Nashville, Tennessee; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, Tennessee.
Cellular and Molecular Gastroenterology and Hepatology
|February 11, 2024
Summary
Fibroblast cells in the human stomach show significant changes during cancer development. These stromal cells, including myofibroblasts and PDGFRA-expressing telocyte-like cells, are crucial to the evolving tumor microenvironment.
Area of Science:
- Gastroenterology
- Oncology
- Cell Biology
Background:
- Gastric carcinogenesis involves complex cellular interactions within the stomach microenvironment.
- Fibroblasts, a key stromal cell type, exhibit heterogeneity and plasticity, influencing cancer progression.
Purpose of the Study:
- To review and discuss recent findings on fibroblast populations in the human stomach.
- To understand the role of fibroblasts in normal gastric tissue, metaplasia, dysplasia, and cancer.
Main Methods:
- Review of single cell RNA sequencing and spatial transcriptomics studies.
- Analysis of fibroblast heterogeneity and plasticity across gastric carcinogenesis stages.
Main Results:
- Fibroblast populations, including myofibroblasts and PDGFRA-expressing telocyte-like cells, change significantly during gastric carcinogenesis.
- These cells are integral to the tumor microenvironment, supporting progenitor niches and contributing matrix proteins.
Conclusions:
- Fibroblast populations are as dynamic as epithelial cells during stomach cancer evolution.
- Understanding fibroblast plasticity is critical for comprehending gastric carcinogenesis.
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