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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

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Classifying systemic lupus erythematosus using laboratory items alone: a preliminary study.

Lin Zhang¹, Jinlu Ma¹, Dong Yan¹

¹Department of Rheumatology and Immunology, the Second Affiliated Hospital of Soochow University, Sanxiang Road No.1055, Suzhou, 215004, Jiangsu, China.

Clinical Rheumatology

|February 11, 2024

Summary

This summary is machine-generated.

Laboratory items alone are effective for classifying systemic lupus erythematosus (SLE). The Systemic Lupus Erythematosus Risk Probability Index (SLERPI) and Systemic Lupus International Collaborating Clinics (SLICC)-2012 criteria, using lab data, are most promising for clinical use.

Keywords:

Classification Diagnosis Laboratory items Systemic lupus erythematosus

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Area of Science:

Rheumatology
Immunology
Clinical Diagnostics

Background:

Systemic lupus erythematosus (SLE) classification relies on diverse criteria.
The role of laboratory findings in SLE classification requires further exploration.

Purpose of the Study:

To assess the performance of laboratory items alone in classifying SLE.
To compare the efficacy of different SLE classification criteria when utilizing only laboratory data.

Main Methods:

Evaluation of ACR-1997, SLICC-2012, EULAR/ACR-2019, and SLERPI criteria using laboratory data.
Analysis of sensitivity and patient identification with modified criteria (mSLICC-2012, mEULAR/ACR-2019).

Main Results:

Laboratory items alone achieved high sensitivity in SLERPI (85.2%) and SLICC-2012 (79.8%).
Modified SLICC-2012 and EULAR/ACR-2019 criteria identified additional SLE patients.
A combination of modified SLICC-2012, modified EULAR/ACR-2019, and SLERPI achieved 90.6% sensitivity.

Conclusions:

Laboratory data alone is clinically feasible for SLE identification.
SLERPI and SLICC-2012 using laboratory items are more clinically valuable than EULAR/ACR-2019.
Simplified evaluation of lab indices can aid non-specialists in early SLE diagnosis.