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Association between pan-immune inflammatory value and ulcerative colitis
Aslıhan Mete Yıldırım1, Oğuzhan Yıldırım2
1Department of Medical Education, Inonu University, Malatya, Turkey.
Current Medical Research and Opinion
|February 12, 2024
Summary
Systemic inflammatory index (SII) and pan-immune inflammatory value (PIV) are elevated in ulcerative colitis patients at diagnosis. These biomarkers correlate with disease severity, aiding in understanding ulcerative colitis activity.
Area of Science:
- Gastroenterology and Hepatology
- Inflammatory Bowel Disease Research
- Biomarker Discovery
Background:
- Ulcerative colitis (UC) is a chronic inflammatory condition of the colon and rectum characterized by relapsing and remitting disease activity.
- Systemic inflammatory index (SII) and pan-immune inflammatory value (PIV) are emerging biomarkers with potential applications in various inflammatory and malignant diseases.
- Existing literature suggests a link between SII and PIV with other inflammatory conditions, but their specific role in UC activity requires further investigation.
Purpose of the Study:
- To investigate the relationship between Systemic inflammatory index (SII) and pan-immune inflammatory value (PIV) and the disease activity in ulcerative colitis (UC) patients.
- To evaluate SII and PIV as potential diagnostic or prognostic markers for ulcerative colitis.
- To compare SII and PIV levels between UC patients and healthy controls.
Main Methods:
- Retrospective analysis of 146 ulcerative colitis patients at the time of diagnosis, incorporating clinical, endoscopic, and histopathological data.
- Calculation and comparison of Systemic inflammatory index (SII) and pan-immune inflammatory value (PIV) levels in UC patients versus healthy individuals.
- Assessment of endoscopic disease severity using Mayo, DUBLIN, and UCIES subscores; ROC curve analysis for PIV cut-off determination.
Main Results:
- Statistically significant differences in Systemic inflammatory index (SII) and pan-immune inflammatory value (PIV) were observed between ulcerative colitis patients and healthy controls (p < .001 for both).
- Pan-immune inflammatory value (PIV) emerged as an independent predictor of ulcerative colitis (OR: 1.157; p = .036).
- The optimal cut-off value for PIV in predicting ulcerative colitis was determined to be ≥ 506, demonstrating 89.6% sensitivity and 63.7% specificity (AUC = 0.812).
Conclusions:
- Systemic inflammatory index (SII) and pan-immune inflammatory value (PIV) levels are significantly elevated in ulcerative colitis patients at diagnosis.
- Both SII and PIV are associated with disease severity, as indicated by endoscopic scoring systems (RACHMILEWITZ, UCEIS, DUBLIN), but not the MES score.
- PIV shows promise as a valuable biomarker for predicting ulcerative colitis and assessing disease activity.
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