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Updated: May 12, 2026

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Published on: July 18, 2014
Tricuspid regurgitation burden following transcatheter aortic valve replacement requiring early pacemaker
Ghadi Moubarak1, Allison T Lanfear1, Mohanad Hamandi1
1Heart Hospital Baylor Plano, Baylor Scott & White Research Institute, Plano, Texas, USA.
Background:
Conduction abnormality requiring the implantation of a permanent pacemaker (PPM) is a well-known and clinically important complication of transcatheter aortic valve replacement (TAVR). However, PPM implantation may result in lead-associated tricuspid valve regurgitation (TR). This study sought to determine the incidence and progression of TR following PPM implantation after TAVR.
Methods:
This was a retrospective review of all echocardiograms of patients who underwent PPM following TAVR at the Baylor Scott & White hospitals from 2012 to 2021. The primary endpoint was TR progression at 30 days and 1 year. A subanalysis comparing the change in TR progression between small and large TAVR devices was also conducted. Secondary outcomes included all-cause death at 30 days and 1 year.
Results:
Out of the 2744 patients who underwent TAVR between April 2012 and August 2021, 177 patients (6.5%) subsequently received a new PPM. There was a statistically significant progression of TR at 1-year follow-up (McNemar's P value = 0.02). TR progression rates were comparable between the small and large valve groups at 1-year follow-up (4% vs 11%, P = 0.09, respectively).
Conclusion:
In this single healthcare system study, we demonstrated a significant progression of TR in patients with PPM post TAVR at 1 year.
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