Establishment of Normal Reference Intervals for Coagulation Test Indicators in Children

Area of Science:

• Pediatric Hematology
• Clinical Biochemistry
• Hemostasis and Thrombosis

Background:

• Establishing age-specific reference intervals for coagulation parameters in children is essential for accurate clinical interpretation.
• Previous studies may lack comprehensive data across diverse pediatric age groups.

Purpose of the Study:

• To determine the standard reference intervals for coagulation function and key coagulation factors in healthy children.
• To stratify these reference intervals across different pediatric age groups.

Main Methods:

• Statistical analysis of prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (Fib), thrombin time (TT), and coagulation factors (II, V, VII, X, VIII, IX, XI, XII).
• Data collected from 389 healthy children aged 1 month to 18 years undergoing routine health checkups or presurgical examinations.
• Children were categorized into four distinct age groups for analysis.

Main Results:

• Normal reference ranges were established for PT, APTT, Fib, TT, and coagulation factors II, V, VII, X, VIII, IX, XI, and XII.
• Specific ranges were defined for different age brackets, including 1 month - 1 year, 1 - 3 years, and 3 - 18 years.
• Significant age-related variations in coagulation parameters were observed.

Conclusions:

• Standard reference intervals for pediatric coagulation function and factors were successfully established in the studied population.
• These established ranges serve as a valuable resource for clinicians in Hangzhou, China, and potentially beyond.
• The findings contribute to improved diagnostic accuracy for hemostatic disorders in children.