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Heparin-binding protein as a biomarker of severe sepsis in the pediatric intensive care unit: A multicenter,

Pengcheng Liu1, Dapeng Chen2, Jintu Lou3

  • 1Department of Clinical Laboratory, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|December 2, 2022
PubMed

Insights

Heparin-binding protein (HBP) shows promise as a biomarker for severe sepsis in children. Declining HBP levels at 72 hours predict lower in-hospital mortality in the pediatric intensive care unit (PICU).

Area of Science:

  • Pediatric critical care medicine
  • Biomarker discovery
  • Sepsis diagnostics

Background:

  • Severe sepsis is a critical condition in pediatric intensive care units (PICUs).
  • Accurate diagnostic and prognostic biomarkers are crucial for timely intervention.
  • Heparin-binding protein (HBP) is being investigated for its potential role.

Purpose of the Study:

  • To evaluate Heparin-binding protein (HBP) as a diagnostic and prognostic biomarker for severe sepsis in the PICU.
  • To compare HBP with established sepsis markers like procalcitonin (PCT) and C-reactive protein (CRP).

Main Methods:

  • A prospective, multicenter study involving 355 children with sepsis in nine Chinese PICUs.
  • Plasma HBP, PCT, CRP, lactate, and white blood cell (WBC) counts were measured at enrollment and 72 hours.
  • Statistical analysis was performed to assess diagnostic and prognostic capabilities.

Main Results:

  • Patients with severe sepsis exhibited significantly higher HBP levels than those with non-severe sepsis (170.5 vs. 74.1 ng/mL).
  • Incorporating HBP into diagnostic models improved severe sepsis detection.
  • Declining HBP levels at 72 hours were strongly associated with reduced in-hospital mortality (aOR 0.242).
  • HBP showed positive correlations with PCT, CRP, and WBC count.

Conclusions:

  • HBP serves as an independent indicator for diagnosing severe sepsis upon enrollment in the PICU.
  • Dynamic changes in HBP levels at 72 hours are a significant predictor of in-hospital mortality.
  • HBP offers valuable insights into sepsis severity and patient outcomes.
Abstract

Keywords:
ChildrenDiagnosisHeparin-binding protein (HBP)Pediatric intensive care unit (PICU)PrognosisSevere sepsis

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