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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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Patterns of antibiotic administration in Chinese neonates: results from a multi-center, point prevalence survey

Jiaosheng Zhang1, Li Lin2, Gen Lu3

  • 1Department of Infectious diseases, Shenzhen Children's Hospital, Shenzhen, China.

BMC Infectious Diseases
|February 12, 2024
PubMed

Insights

Broad-spectrum antibiotic overuse in Chinese neonates is highlighted, with a focus on the World Health Organization

Area of Science:

  • Neonatal pharmacology and infectious disease management.
  • Global antibiotic stewardship initiatives.
  • Public health policy in China.

Background:

  • Antibiotic prescribing patterns in neonates are crucial for combating antimicrobial resistance.
  • The World Health Organization (WHO) Essential Medicines List (EML) categorizes antibiotics into Access, Watch, and Reserve (AWaRe) groups to guide appropriate use.
  • China's Management of Antibiotic Classification (MAC) Guidelines further stratify antibiotic use.

Purpose of the Study:

  • To analyze antibiotic prescription patterns in hospitalized neonates in China.
  • To evaluate these patterns against the WHO AWaRe and China's MAC Guidelines.
  • To identify potential areas for antibiotic stewardship improvement in neonatal care.

Main Methods:

  • One-day point-prevalence surveys (PPS) were conducted annually from 2017 to 2019.
  • Data collected from 15 hospitals across 9 Chinese provinces.
  • Prescriptions for 1520 neonates receiving antibiotics were analyzed.

Main Results:

  • Meropenem was the most frequently prescribed antibiotic (11.8%).
  • Pneumonia was the leading indication for antibiotic use (44.2%).
  • A significant proportion of prescriptions fell into the WHO 'Watch' (69.1%) and China's MAC 'Special' (21.3%) categories.

Conclusions:

  • Overuse of broad-spectrum antibiotics, particularly those in the 'Watch' and 'Special' categories, was observed in Chinese neonates.
  • This suggests a need for enhanced antibiotic stewardship programs in neonatal intensive care units.
  • Current prescribing practices may contribute to the development of antimicrobial resistance.
Abstract

Keywords:
AntibioticChinaNeonatesPatternPrescription

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