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Lymphatic Vessels in Chronic Rhinosinusitis.

Vanessa-Vivien Pesold1, Olaf Wendler1, Franziska Gröhn2

  • 1Department of Otolaryngology, Head and Neck Surgery, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, BY, Germany.

Journal of Inflammation Research
|February 13, 2024
PubMed
Summary
This summary is machine-generated.

Chronic rhinosinusitis (CRS) may involve impaired nasal lymphatic function, leading to fluid buildup and inflammation. Hyaluronic acid and macrophage accumulation in nasal polyps suggest new factors in CRS pathogenesis.

Keywords:
chronic rhinosinusitischronic rhinosinusitis with nasal polypshyaluronic acidinflammationlymphangiogenesismucus

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Area of Science:

  • Rhinology
  • Immunology
  • Pathophysiology

Background:

  • Chronic rhinosinusitis (CRS) is a complex inflammatory condition of the nasal mucosa.
  • The role of the nasal lymphatic system in CRS pathogenesis remains incompletely understood.

Purpose of the Study:

  • To investigate the nasal lymphatic system in chronic rhinosinusitis with (CRSwNP) and without nasal polyps (CRSsNP).
  • To identify novel factors potentially involved in the pathogenesis of CRS.

Main Methods:

  • Quantification of lymphatic vessels (LVs) and macrophages in sinonasal tissues from CRS patients and controls.
  • Analysis of lymphatic vessel endothelial receptor 1 (LYVE-1), matrix metalloproteinase 14 (MMP-14), and Hyaluronic acid (HA) in tissue lysates and nasal secretions using ELISA.
  • Correlation of HA levels with macrophage counts.

Main Results:

  • Significantly reduced LV counts in both CRS groups compared to controls.
  • Differential expression of LYVE-1 and overexpression of MMP-14 in CRSwNP tissues.
  • Underexpression of LYVE-1 and HA in nasal secretions of CRS patients.
  • Accumulation of HA and macrophages beneath the epithelium in nasal polyps, with a positive correlation between HA and macrophage levels.

Conclusions:

  • Impaired lymphatic drainage may contribute to CRS.
  • Accumulation of HA and macrophages could promote inflammation, edema, and polyp formation.
  • These findings highlight potential novel factors in CRS pathogenesis.