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Single Nucleotide Polymorphisms in Coronary Microvascular Dysfunction

Andrew P Stein1, Jonathan Harder1, Henry R Holmes1

  • 1Department of Medicine University of Florida Gainesville FL USA.

Journal of the American Heart Association
|February 13, 2024
PubMed

Insights

Coronary microvascular dysfunction may have genetic links. This review explores single nucleotide polymorphisms associated with this condition, offering insights into its potential genetic basis.

Area of Science:

  • Cardiology
  • Genetics
  • Pathology

Background:

  • Coronary microvascular dysfunction (CMD) is an underdiagnosed condition linked to poor clinical outcomes.
  • Emerging evidence suggests a potential genetic component influencing CMD development.
  • Understanding genetic factors is crucial for advancing CMD diagnosis and treatment.

Purpose of the Study:

  • To provide an updated review of single nucleotide polymorphisms (SNPs) associated with coronary microvascular dysfunction.
  • To synthesize current knowledge on the genetic underpinnings of CMD.
  • To highlight the role of genetic variations in CMD pathogenesis.

Main Methods:

  • Literature review of studies investigating genetic polymorphisms and CMD.
  • Analysis of published data on single nucleotide polymorphisms relevant to coronary microvascular function.
  • Synthesis of findings from genetic association studies.

Main Results:

  • Identification of specific single nucleotide polymorphisms implicated in coronary microvascular dysfunction.
  • Summary of genetic variants potentially influencing endothelial function and vascular tone.
  • Overview of the current genetic landscape of CMD.

Conclusions:

  • Genetic factors, particularly specific SNPs, may play a significant role in the susceptibility and manifestation of coronary microvascular dysfunction.
  • Further research into the genetic determinants of CMD is warranted.
  • Genetic insights could lead to novel diagnostic and therapeutic strategies for CMD.
Keywords:
coronary microvascular dysfunctionsingle nucleotide polymorphism, genetic

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