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Coagulation and Inflammation in COVID-19: Reciprocal Relationship between Inflammatory and Coagulation Markers

Rasoul Ebrahimi1, Fatemeh Nasri1, Tahereh Kalantari2

  • 1Division of Laboratory Hematology and Blood Banking, Department of Medical Laboratory Sciences, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.

Annals of Hematology
|February 13, 2024
PubMed

Insights

Severe inflammation and blood clotting issues, known as coagulopathy, are hallmarks of COVID-19. These processes, including NETosis, are interconnected and influence each other in severe coronavirus disease 2019.

Area of Science:

  • Medical Science
  • Pathophysiology
  • Infectious Diseases

Background:

  • COVID-19, caused by SARS-CoV-2, presents with significant cellular and biochemical disruptions.
  • Severe inflammation, driven by cytokines, is a primary characteristic of COVID-19.
  • Coagulopathy and thrombotic events are frequently observed in severe COVID-19 cases.

Purpose of the Study:

  • To review the key hallmarks of COVID-19, focusing on inflammation and coagulation.
  • To explore the relationship between inflammation and coagulation pathways in COVID-19.
  • To discuss the role of NETosis in the interplay between inflammation and coagulation.

Main Methods:

  • Literature review of COVID-19 pathophysiology.
  • Analysis of inflammation and coagulation markers in COVID-19.
  • Discussion of NETosis as a link between inflammation and coagulation.

Main Results:

  • COVID-19 is characterized by severe inflammation and coagulopathy.
  • Inflammation and coagulation markers are significantly altered in COVID-19 patients.
  • NETosis plays a crucial role in the integrated inflammatory and coagulation response.

Conclusions:

  • Inflammation and coagulation are interconnected systems in COVID-19.
  • Inflammation can activate coagulation, and conversely, coagulation can activate inflammation.
  • Understanding this bidirectional relationship is key to managing severe COVID-19.

Keywords:
COVID-19Coagulation markersFibrinolysis systemInflammation markersInterleukinsProtein C-protein S system

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