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Published on: May 10, 2017
B-cell ALL with SOX11 gene amplification associates with a worse outcome
George Angelakakis1, Mallika Varkhedi1, Toriana R Dabkowski1
1Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Abstract:
Copy number variation (CNV) of certain genes in pediatric Acute Lymphoblastic Leukemia (ALL) impacts gene expression levels. Here, we aimed to investigate the potential prognostic utility of CNVs in pediatric B-ALL and T-ALL. Using genomics files representing cases from the TARGET-ALL-P2 dataset, genes commonly involved in ALL development were analyzed for CNVs. Case IDs representing increased copy numbers for SOX11, PDGFRB, and MDK represented a worse overall survival probability specifically for B-ALL (logrank p=0.021, p=0.0052, p=0.019, respectively). These data support the continued investigation of using CNVs for clinical prognostic biomarkers for pediatric B-ALL.
