Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Structural brain alterations in autism: A large-scale voxel-based morphometry mega-analysis.

bioRxiv : the preprint server for biology·2026
Same author

Global Socioeconomic Context and Brain Ageing in Epilepsy: an ENIGMA-Epilepsy study.

medRxiv : the preprint server for health sciences·2026
Same author

Shared and specific associations of amygdala nuclei volumes with PTSD symptom domains and childhood trauma: An ENIGMA-PGC PTSD mega-analysis.

Molecular psychiatry·2026
Same author

Variations of global brain asymmetry are associated with aging and related diseases.

Science advances·2026
Same author

Regional, functional and transcriptomic decoding of multidimensional brain structure alterations in obsessive-compulsive disorder.

Nature communications·2026
Same author

Decomposing neuroanatomical heterogeneity in depression: insights from an ENIGMA major depressive disorder working group study in 5146 individuals.

Translational psychiatry·2026

Related Experiment Video

Updated: Jul 3, 2025

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
17:06

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

26.2K

Sex Differences in the Brain's White Matter Microstructure during Development assessed using Advanced Diffusion MRI

Sebastian M Benavidez1, Zvart Abaryan2, Gaon S Kim1

  • 1Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, University of Southern California, Marina del Rey, CA, USA.

Biorxiv : the Preprint Server for Biology
|February 14, 2024
PubMed
Summary

This study found significant sex differences in white matter (WM) microstructure in neurotypical individuals aged 5-22. Advanced diffusion MRI models, particularly the tensor distribution function (TDF), were most sensitive in detecting these developmental variations.

Keywords:
diffusion-weighted MRIsex differenceswhite matter

More Related Videos

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
12:21

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

25.2K
Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

28.4K

Related Experiment Videos

Last Updated: Jul 3, 2025

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
17:06

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

26.2K
Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
12:21

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

25.2K
Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

28.4K

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Medical Imaging

Background:

  • Sex differences in brain development are not fully understood.
  • White matter (WM) microstructure plays a crucial role in brain function and connectivity.
  • Previous research has limitations in characterizing these sex-based developmental variations.

Approach:

  • Utilized diffusion-weighted MRI (dMRI) on 239 neurotypical individuals (aged 5-22).
  • Employed conventional diffusion tensor imaging (DTI) and advanced models: tensor distribution function (TDF) and neurite orientation dispersion density imaging (NODDI).
  • Analyzed sex differences in WM microstructure across various brain regions.

Key Points:

  • Significant and regionally consistent sex differences in WM microstructure were observed during typical development.
  • The tensor distribution function (TDF) model demonstrated superior sensitivity in identifying these sex-based differences compared to DTI and NODDI.
  • Findings reveal distinct developmental trajectories for male and female white matter.

Conclusions:

  • Sex is an important biological variable to consider in neurodevelopmental research.
  • Advanced dMRI models like TDF offer enhanced insights into subtle microstructural variations.
  • This study provides a foundation for understanding sex-specific brain development and potential implications for neurological conditions.