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Updated: Jul 3, 2025

Dissection and Culture of Mouse Embryonic Kidney
Published on: May 17, 2017
Shared features in ear and kidney development - implications for oto-renal syndromes
Scarlet Xiaoyan Wang1, Andrea Streit1
1Centre for Craniofacial and Regenerative Biology, King's College London, London SE1 9RT, UK.
Abstract:
The association between ear and kidney anomalies has long been recognized. However, little is known about the underlying mechanisms. In the last two decades, embryonic development of the inner ear and kidney has been studied extensively. Here, we describe the developmental pathways shared between both organs with particular emphasis on the genes that regulate signalling cross talk and the specification of progenitor cells and specialised cell types. We relate this to the clinical features of oto-renal syndromes and explore links to developmental mechanisms.
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