Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Biological Effects of Radiation

Biological Effects of Radiation

All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Comparison of integrated biological effectiveness of eye plaques with <sup>125</sup>I and <sup>103</sup>Pd photon sources using equivalent uniform RBE-weighted dose.

Medical physics·2025

Same author

Assessment of equivalent uniform RBE-weighted dose in hypofractionated proton therapy for ocular melanoma.

Biomedical physics & engineering express·2025

Same author

Adjuvant Brachytherapy Using Iodine-125 Plaques for Conjunctival Melanoma with Scleral Invasion.

Seminars in ophthalmology·2025

Same author

Biological effectiveness of uniform and nonuniform dose distributions in radiotherapy for tumors with intermediate oxygen levels.

Biomedical physics & engineering express·2024

Same author

Equivalent uniform aerobic dose in radiotherapy for hypoxic tumors.

Physics in medicine and biology·2024

Same author

Tumor control probability in hypofractionated radiotherapy as a function of total and hypoxic tumor volumes.

Physics in medicine and biology·2021

Search research articles

Related Experiment Video

Updated: Jul 3, 2025

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

Equivalent uniform RBE-weighted dose in eye plaque brachytherapy.

Alexei V Chvetsov¹

¹Department of Radiation Oncology, University of Washington, Seattle, Washington, USA.

Medical Physics

|February 14, 2024

Summary

A new metric, equivalent uniform RBE-weighted dose (EUD_RBE), quantifies cell survival in ocular melanoma brachytherapy. This tool accounts for variable dose rates and relative biological effectiveness (RBE), improving treatment comparisons.

Keywords:

BED EUD LQ model RBE eye plaque brachytherapy

More Related Videos

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

Related Experiment Videos

Last Updated: Jul 3, 2025

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

Area of Science:

Radiation Oncology
Medical Physics
Ophthalmology

Background:

Ocular melanoma brachytherapy utilizes eye plaques with varying dose distributions, rates, and relative biological effectiveness (RBE).
Accurate dosimetry is crucial for optimizing treatment outcomes and minimizing side effects.

Purpose of the Study:

To introduce the equivalent uniform RBE-weighted dose (EUD_RBE) for quantitative assessment of cell survival.
To apply EUD_RBE to ¹²⁵I eye plaque brachytherapy for ocular melanoma, considering variable RBE, dose, and dose rate.

Main Methods:

Defined EUD_RBE as a uniform dose (RBE=1) yielding equal cell survival to a non-uniform dose (RBE>1).
Modeled ¹²⁵I COMS eye plaque brachytherapy, incorporating steep dose gradients, protracted irradiation (3-8 days), and dose-rate dependent RBE (max 1.4).
Converted physical dose distributions to biologically effective dose (BED) to account for sublethal repair and protracted irradiation.

Main Results:

EUD_RBE increased with prescription depth (up to 6% for 12mm tumor height) due to steep dose gradients.
Increasing dose rate (decreasing implant duration) increased EUD_RBE by up to 12%.
Combined effects of dose non-uniformity and dose rate altered EUD_RBE by up to 18% for an 85 Gy prescription.

Conclusions:

The calculated EUD_RBE range for ¹²⁵I COMS eye plaque brachytherapy validates the chosen models and hypotheses.
EUD_RBE offers a valuable tool for analyzing treatment outcomes and comparing dose regimens in ocular brachytherapy.