Related Experiment Video
Updated: Jul 3, 2025
08:40
Chronic Salmonella Infection Induced Intestinal Fibrosis
Published on: September 22, 2019
7.1K
Idiopathic terminal ileitis: myth or true entity?
Nicoletta Nandi1,2, Foong Way David Tai1,3, Mark McAlindon1,3
1Academic Unit of Gastroenterology and Hepatology, Sheffield Teaching Hospitals, NHS Foundation Trust, Sheffield, UK.
Current Opinion in Gastroenterology
|February 14, 2024
Summary
Idiopathic terminal ileitis (IDTI) is a diagnosis of exclusion that presents diagnostic and management challenges. While uncommon, some patients may progress to Crohn's disease, necessitating careful follow-up.
Area of Science:
- Gastroenterology
- Internal Medicine
Background:
- Idiopathic terminal ileitis (IDTI) is an increasingly recognized condition found during colonoscopy.
- It is a diagnosis of exclusion, posing challenges in both diagnosis and management.
- The prevalence of IDTI ranges from 0.5% to 7%.
Approach:
- This review synthesizes current evidence on idiopathic terminal ileitis.
- Focuses on the condition's evolution, natural history, and proposed management strategies.
- Highlights the diagnostic challenges and differential diagnoses, including Crohn's disease and intestinal tuberculosis.
Key Points:
- A significant proportion of IDTI patients (0-50%) may develop Crohn's disease over time.
- Currently, no reliable predictive factors exist to stratify IDTI patients for risk of progression.
- Noninvasive methods like capsule endoscopy are valuable for monitoring patients.
Conclusions:
- Idiopathic terminal ileitis requires ongoing patient follow-up due to potential progression to Crohn's disease.
- Further research is essential to enhance understanding and management of this entity.
- Capsule endoscopy offers a useful noninvasive approach for patient monitoring.
Related Concept Videos
01:30Inflammatory Bowel Disease II: Crohn's Disease
244
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
244
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
185
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
185
01:17Irritable Bowel Syndrome I: Introduction
275
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
275
01:22Appendicitis-I: Introduction
145
The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
145
01:17Chronic Bowel Disorders: Introduction
450
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
450
01:30Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
161
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
161