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Incidence and risk factors for long COVID in children with COVID-19 pneumonia
Na-Bhadhra Wongwathanavikrom1, Prakarn Tovichien1, Kanokporn Udomittipong1
1Department of Pediatrics, Division of Pulmonology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Insights
Nearly 40% of children experienced long COVID after pneumonia, with persistent symptoms like exercise intolerance and cough. Older children, severe cases, those with allergies, or living in polluted areas face higher risks.
Area of Science:
- Pediatric Pulmonology
- Infectious Diseases
- Public Health
Background:
- Limited data exists on long COVID and pulmonary function in children post-COVID-19 pneumonia.
- This study addresses the incidence and risk factors of long COVID in pediatric patients.
Purpose of the Study:
- To determine the incidence of long COVID in children following COVID-19 pneumonia.
- To assess pulmonary function abnormalities in these children.
- To identify risk factors associated with developing long COVID.
Main Methods:
- A cohort study involving children admitted with COVID-19 pneumonia between 2021-2022.
- Clinical data collected during admission and at a 3-month follow-up.
- Pulmonary function tests and chest radiographs were utilized.
Main Results:
- The incidence of long COVID was 39.7%.
- Common persistent symptoms included exercise intolerance (22.4%), cough (18.1%), and fatigue (15.5%).
- Significant risk factors identified were older age, allergic diseases, and living in polluted areas.
Conclusions:
- A substantial proportion of children develop long COVID after COVID-19 pneumonia.
- Children with exercise intolerance, chronic cough, or fatigue require close monitoring.
- Targeted attention is crucial for older children, severe cases, those with allergies, and those residing in polluted environments.
Background And Objective:
There are only a few reports of long COVID including pulmonary function in children after COVID-19 pneumonia. We determined the incidence of long COVID and abnormal pulmonary function in those children and identify risk factors.
Methods:
This cohort study enrolled children admitted with COVID-19 pneumonia during 2021-2022. We gathered clinical characteristics during admission and at follow-up 3 months after.
Results:
We determined the incidence of long COVID at 39.7% (95% confidence interval [CI]: 30.7%-49.1%). All severe pneumonia cases consistently reported persistent symptoms. Exercise intolerance, cough, and fatigue were the three most common persistent symptoms in 26 (22.4%), 21 (18.1%), and 18 (15.5%) of the patients, respectively. At the follow-up, 21 cases (18.1%) demonstrated persistent abnormal chest radiographs. Three cases (6.9%) demonstrated restrictive ventilatory defects. Among those, one case (2.3%) demonstrated concomitant diffusion defect. Three cases (6.0%) demonstrated exercise-induced hypoxemia after the 6-minute walk test. Comparing spirometry variables between children with long COVID and without revealed significant difference of FEF25-75 (z score) between two groups. Age [adjusted OR (95% CI): 1.13 (1.05-1.22), p value 0.002], allergic diseases [adjusted OR (95% CI): 4.05 (1.36-12.06), p value 0.012], and living in polluted areas [adjusted OR (95% CI): 2.73 (1.18-6.33), p value 0.019] were significantly associated with long COVID.
Conclusion:
A significant percentage of children developed long COVID after COVID-19 pneumonia. We should give additional attention to those who have exercise intolerance, chronic cough, or fatigue, especially older children, severe cases, children with allergic diseases, and those living in polluted areas.
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