Prognostication in Lymph Node-Positive Prostate Cancer with No PSA Persistence After Radical Prostatectomy.

Area of Science:

• Urology
• Oncology
• Prognostic Modeling

Background:

• Prostate cancer recurrence prediction is crucial for patient management.
• Patients with lymph node involvement but no PSA persistence require accurate prognostic tools.

Purpose of the Study:

• To develop a prognostic model for predicting disease recurrence in prostate cancer patients with lymph node involvement.
• To assess the clinical utility of this prognostic model.

Main Methods:

• Analysis of 231 patients with lymph node involvement post-radical prostatectomy and no PSA persistence (2006-2019).
• Utilized Cox proportional hazards model to identify prognostic factors for recurrence-free survival (RFS).

Main Results:

• Identified key prognostic factors for RFS: PSA level at diagnosis, International Society of Urological Pathology grade group, pathologic T-stage, and surgical margin status.
• The developed prognostic model demonstrated association with RFS and metastasis-free survival.

Conclusions:

• The prognostic model, incorporating postoperative PSA and lymph node count, is clinically valuable.
• This model facilitates informed treatment discussions with patients regarding recurrence risk.