Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The schema spectrum: Emergent structures and levels of abstraction in AI and the brain.

Neuron·2026
Same author

RNA sensors and actuators for dynamic cellular regulation.

Trends in biotechnology·2026
Same author

Construction of Peptide Amphiphile-Coated Coacervates with Selective Permeability.

ACS biomaterials science & engineering·2026
Same author

RetINaBox: A Hands-On Learning Tool for Experimental Neuroscience.

eNeuro·2026
Same author

Protein-Based Nanostructures: Column-free Biosynthesis of Bundlemer Peptides with Programmable, Orthogonally Reactive Handles for Nanomaterial Construction.

ACS applied materials & interfaces·2025
Same author

MIMIC-MJX: Neuromechanical Emulation of Animal Behavior.

ArXiv·2025

Related Experiment Video

Updated: May 12, 2026

Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry
08:51

Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry

Published on: March 1, 2013

15.9K

Engineering protein nanoparticles for drug delivery.

Blake A Richards1, Antonio G Goncalves1, Millicent O Sullivan1

  • 1Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE 19716, USA.

Current Opinion in Biotechnology
|February 14, 2024
PubMed
Summary

Protein nanoparticles are versatile platforms for engineering advanced drug delivery systems. This review highlights three distinct nanoparticles, detailing their tunable properties and generalized engineering techniques for improved drug efficacy and reduced side effects.

More Related Videos

Manufacture and Drug Delivery Applications of Silk Nanoparticles
09:03

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

15.8K
Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability
07:41

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability

Published on: July 12, 2024

2.2K

Related Experiment Videos

Last Updated: May 12, 2026

Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry
08:51

Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry

Published on: March 1, 2013

15.9K
Manufacture and Drug Delivery Applications of Silk Nanoparticles
09:03

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

15.8K
Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability
07:41

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability

Published on: July 12, 2024

2.2K

Area of Science:

  • Biotechnology and Nanomedicine
  • Materials Science

Background:

  • Protein nanoparticles are adaptable for creating sophisticated drug delivery vehicles.
  • They offer potential for enhanced therapeutic efficacy and minimized off-target effects.
  • Genetic and posttranslational modifications are key to their functionalization.

Purpose of the Study:

  • To review three protein nanoparticle systems of increasing size for drug delivery applications.
  • To highlight their unique properties, including tunable stability and modular surface decoration.
  • To discuss generalized engineering approaches applicable across various protein nanoparticle platforms.

Main Methods:

  • Focus on three distinct protein nanoparticle systems.
  • Analysis of their inherent properties: size-dependent characteristics, stability, subunit fusion/fission capabilities, and conformational changes.
  • Review of genetic and posttranslational modification strategies.

Main Results:

  • Each protein nanoparticle exhibits unique, tunable characteristics suitable for drug delivery.
  • Modular surface decoration is achievable through subunit manipulation.
  • Significant capacity for large protein cargos is demonstrated.
  • Common engineering techniques are identified across platforms.

Conclusions:

  • Protein nanoparticles represent a highly tunable platform for multifunctional drug delivery.
  • Shared engineering techniques facilitate broad applicability and development.
  • These platforms hold promise for improving drug delivery efficacy and safety.