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Related Experiment Video

Updated: Jul 3, 2025

A Data-Driven Approach to Quantifying Immune States in Sepsis
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A Data-Driven Approach to Quantifying Immune States in Sepsis

Published on: February 7, 2025

170

[Immunometabolism in Sepsis].

Björn Koos, Matthias Unterberg, Tim Rahmel

    Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS
    |February 14, 2024
    PubMed
    Summary

    Immunometabolism links immune responses and metabolism, crucial for sepsis. Immune cells shift to glycolysis and pentose phosphate pathway (PPP) for energy, impacting inflammation and potentially offering therapeutic targets.

    Area of Science:

    • Immunometabolism: The intersection of immunology and cellular metabolism.
    • Investigates how metabolic pathways regulate immune cell function and inflammatory responses.

    Context:

    • Sepsis involves a complex interplay between the immune system and metabolic processes.
    • Proinflammatory immune responses during sepsis demand significant energy, altering cellular metabolism.

    Purpose:

    • To elucidate the metabolic shifts occurring in immune cells during sepsis.
    • To understand the bidirectional relationship between immune reactions and metabolic pathways.

    Summary:

    • During sepsis, immune cells increase glycolysis and pentose phosphate pathway (PPP) activity for rapid energy (ATP) and NADPH production, essential for macromolecule synthesis and redox balance.
    • The citric acid cycle is downregulated, leading to citrate and succinate accumulation, indicating mitochondrial dysfunction. Heightened glycolysis produces lactate, a sepsis biomarker.

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  • Anti-inflammatory states reverse these metabolic changes, reactivating the citric acid cycle.

    • Impact:

    • Understanding these immunometabolic alterations is key to managing sepsis.
    • Metabolic pathway modulation presents a potential therapeutic strategy for sepsis treatment.