[Biochemical changes in the myocardium in experimental chronic pirazofos poisoning]

The authors investigate the 12 month effect of the organophosphorus pesticide "Pyrazophos", in the myocardium status of albino male rats treated per os by 1/20, 1/100, and 1/200 LD50 of the preparation /LD50 for male rats 218 mg/kg/. The enzyme activity of ATP-ase, G6P-ase, F1,6 P-ase, PGlM, LDH, SucDH, iCDH, the quantity of soluble and insoluble collagen and elastin proteins were examined as well as the content of polycarbohydrate components /total and sulphated glycosaminoglycan and glycoproteins/ of the basic intercellular substance. The results point out that the preparation in doses 1.1 and 2.2 mg/kg and especially 11 mg/kg at continuous introduction cause cardiotoxic effect, and the changes affect first of all the components of the basic intercellular substance /with sGAG, GAG/ and to a lighter extent the enzyme activity in the cardiac muscle. The collagen and elastin proteins, constructing the fibrous structures remain comparatively stable. The experimental data have to be taken into consideration in the hygiene standardization of the organophosphorus preparation "Pyrazophos".