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Rab10 Phosphorylation Detection by LRRK2 Activity Using SDS-PAGE with a Phosphate-binding Tag
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VPS13C regulates phospho-Rab10-mediated lysosomal function in human dopaminergic neurons

Leonie F Schrӧder1,2, Wesley Peng1, Ge Gao1

  • 1Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

The Journal of Cell Biology
|February 15, 2024
PubMed
Summary

Loss of VPS13C disrupts lysosomal function in human dopaminergic neurons, impacting cellular health. This dysfunction, involving Rab10, contributes to Parkinson's disease pathogenesis.

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