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Updated: Jul 3, 2025

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA

Published on: December 19, 2019

Case 312.

Sanchita Gupta¹, Namita Mohindra¹, Anurag Mehndiratta¹

¹From the Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raibareli Road, Lucknow, Uttar Pradesh, India 226014.

|February 15, 2024

Summary

This summary is machine-generated.

This case study highlights a rare genetic disorder causing painful breast lesions in a young woman. Early ultrasound diagnosis is crucial for identifying these benign, non-cancerous growths.

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Area of Science:

Medical imaging and diagnostics
Genetics and hereditary conditions
Dermatology and endocrinology

Background:

A 29-year-old woman presented with noncyclical mastalgia and palpable breast lesions.
Family history revealed breast cancer in her mother and grandmother, prompting further investigation.
Patient was undergoing treatment for generalized anxiety disorder with selective serotonin receptor inhibitors.

Observation:

Physical examination revealed multiple small, mobile, painful lesions in bilateral breasts, anterior abdominal wall, and forearm.
Ultrasound (US) of bilateral breasts, including Color Doppler and shear-wave elastography, visualized these lesions.
Similar subcutaneous lesions were identified on the anterior abdominal wall and right forearm.

Findings:

Laboratory investigations, including complete blood count and erythrocyte sedimentation rate, were within normal limits.
Imaging findings suggested benign, non-cancerous lesions, despite the family history of breast cancer.
The widespread distribution of lesions across multiple body areas was a notable observation.

Implications:

This case underscores the importance of comprehensive evaluation for unexplained painful lesions, considering genetic predispositions.
Advanced imaging techniques like ultrasound and elastography are vital for characterizing such lesions.
Further investigation into the specific genetic etiology of these widespread benign lesions is warranted.