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Motion-compensated image reconstruction for improved kidney function assessment using dynamic contrast-enhanced MRI.

Cemre Ariyurek1,2, Aziz Koçanaoğulları1,2, Onur Afacan1,2

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A new motion correction technique for dynamic contrast-enhanced MRI significantly improves image quality and renal function assessment in pediatric kidney patients. This method enhances signal-to-noise ratio and reduces errors in kinetic modeling for more reliable results.

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Area of Science:

  • Medical Imaging
  • Radiology
  • Pediatric Nephrology

Background:

  • Accurate renal function measurement is vital for pediatric kidney disease management.
  • Dynamic contrast-enhanced MRI (DCE-MRI) offers a safe method for assessing renal function and anatomy.
  • Motion artifacts in DCE-MRI compromise image quality and diagnostic reliability.

Purpose of the Study:

  • To introduce and evaluate a motion-compensated reconstruction technique for pediatric DCE-MRI.
  • To address challenges posed by respiratory and bulk motion artifacts in DCE-MRI data.
  • To improve the accuracy and reliability of renal function assessment using DCE-MRI.

Main Methods:

  • Developed a motion correction (MoCo) technique for golden-angle radial DCE-MRI data.
  • Incorporated outlier removal using Gaussian process model fitting and center navigator.
  • Implemented data clustering into motion phases, interphase registration, and motion-compensated radial reconstruction.

Main Results:

  • MoCo reconstruction increased temporal signal-to-noise ratio by an average of 21.8%.
  • Significant improvements observed in total variation of aorta and kidney concentration curves (32.5%-42.9% increase).
  • Reduced median standard deviation of filtration rate, nRMSE, and chi-square goodness-of-fit for kinetic modeling.

Conclusions:

  • The proposed MoCo technique effectively mitigates motion artifacts in pediatric DCE-MRI.
  • Enhanced image quality and improved tracer kinetic model fitting lead to more reliable renal function assessment.
  • This method supports better anatomical evaluation and functional assessment in pediatric patients with kidney conditions.