Experimental comparative renal toxicity of lithium and rubidium

Rat kidney was perfused using Krebs solution containing 3 or 6 mEq/l lithium or 3 or 6 mEq/l rubidium; the histological lesions thus induced were compared. Rubidium-induced lesions, irrespective of concentrations, consisted of tubular dilations, degeneration and necrosis very similar to those induced by lower concentrations of lithium; moreover, Bowman space alterations were observed. In contrast, lithium-induced damage was dose-dependent: 6 mEq/l solution induced severe tubular damage with necrosis, endoluminal cellular debris and hyaline substance.