Enantioselective nickel-catalyzed Mizoroki-Heck cyclizations of amide electrophiles
Ana S Bulger1, Daniel J Nasrallah1, Arismel Tena Meza1
1Department of Chemistry and Biochemistry, University of California at Los Angeles Los Angeles California 90095 USA neilgarg@chem.ucla.edu.
Abstract:
Amide cross-couplings that rely on C-N bond activation by transition metal catalysts have emerged as valuable synthetic tools. Despite numerous discoveries in this field, no catalytic asymmetric variants have been disclosed to date. Herein, we demonstrate the first such transformation, which is the Mizoroki-Heck cyclization of amide substrates using asymmetric nickel catalysis. This proof-of-concept study provides an entryway to complex enantioenriched polycyclic scaffolds and advances the field of amide C-N bond activation chemistry.
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