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Disorders of the Urinary System

Disorders of the Urinary System

The urinary system is responsible for eliminating waste and excess fluids from the body. However, disorders of the urinary system can arise due to various reasons like infections, stress, age, congenital abnormalities, and lifestyle.
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...

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Related Experiment Video

Updated: Jul 3, 2025

A Murine Model of Irreversible and Reversible Unilateral Ureteric Obstruction

A Murine Model of Irreversible and Reversible Unilateral Ureteric Obstruction

Published on: December 20, 2014

Abnormal urodynamic changes in post-upper urinary tract dysfunction in ureteral obstruction rat models.

Xin Liu^1,2,3,4,5, Xing Li^2,6, Limin Liao^1,2,3,4,5,6

¹Shandong University, Jinan, Shandong, China.

Frontiers in Physiology

|February 16, 2024

Summary

This summary is machine-generated.

Upper urinary tract dysfunction (UUTD) leads to abnormal urodynamics (UUTU). Increased Piezo1 expression in ureteral tissues is identified as a potential molecular mechanism driving these changes.

Keywords:

Piezo1 mechanosensitive channel upper urinary tract dysfunction upper urinary tract urodynamics ureteral obstruction

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Published on: March 4, 2022

Area of Science:

Urology
Physiology

Background:

Upper urinary tract dysfunction (UUTD) can significantly alter normal urodynamics (UUTU).
Understanding the underlying mechanisms of UUTD-induced UUTU is crucial for developing effective treatments.

Purpose of the Study:

To investigate the changes in upper urinary tract urodynamics following the induction of UUTD.
To explore the role of Piezo1 expression in the development of abnormal UUTU.

Main Methods:

A unilateral ureteral obstruction model was used to induce UUTD.
Renal pelvis volume, resting pressure, and ureteral electromyography (EMG) were measured.
Ureteral tissue analysis included histological staining and Western blotting for Piezo1 expression.

Main Results:

UUTD led to increased renal pelvis volume and resting pressure, along with ureteral tissue edema, necrosis, and fibrosis.
Ureteral contractility and Piezo1 expression were significantly elevated in the UUTD model compared to controls.
Piezo1 was predominantly expressed in the urothelium and suburothelium layers of the ureter.

Conclusions:

Morphological and electrophysiological changes in the upper urinary tract are key mechanisms in abnormal UUTU.
Elevated Piezo1 expression represents a novel molecular mechanism contributing to abnormal urodynamics in UUTD.