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The Association between NADPH Oxidase 2 (NOX2) and Drug Resistance in Cancer

Shiqi Dong1, Chao Chen2, Chang Di3

  • 1Department of Pharmacy, Harbin Medical University Cancer Hospital, Harbin, 150086, China.

Current Cancer Drug Targets
|February 16, 2024
PubMed

Insights

NADPH oxidase 2 (NOX2) generates reactive oxygen species (ROS) that impact tumor cells. Understanding NOX2

Area of Science:

  • Biochemistry
  • Oncology
  • Immunology

Background:

  • NADPH oxidase (NOX) enzymes are key sources of intracellular reactive oxygen species (ROS).
  • NADPH oxidase 2 (NOX2) plays a significant role in immune and oxidative stress responses.
  • The role of NOX2 in tumor development and its relationship with anti-tumor drug resistance are increasingly important research areas.

Purpose of the Study:

  • To systematically review the NOX family, focusing on NOX2.
  • To explore the dual role of NOX2-mediated ROS in tumor drug resistance.
  • To provide an updated classification of NOX2 inhibitors and agonists.

Main Methods:

  • Literature review of NOX family members, particularly NOX2.
  • Analysis of existing research on NOX2 expression and anti-tumor drug resistance.
  • Compilation of current NOX2 inhibitors and agonists.

Main Results:

  • NOX2 is implicated in tumor cell development and immune responses.
  • NOX2-mediated ROS may enhance the efficacy of certain anti-tumor drugs.
  • Limited studies have focused on the direct link between NOX2 expression and drug resistance.

Conclusions:

  • A comprehensive understanding of NOX2's function in tumor drug resistance is needed.
  • NOX2 presents a potential therapeutic target for overcoming cancer drug resistance.
  • This review offers insights for developing novel oncology treatments.
Keywords:
NADPH oxidase 2ROScancercancer drug developmentdrug resistancetumor.

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