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Updated: Jul 3, 2025

Influenza A Virus Studies in a Mouse Model of Infection
Published on: September 7, 2017
Pathogenesis and virulence of coronavirus disease: Comparative pathology of animal models for COVID-19
Natalie M Kirk1, Yuying Liang1, Hinh Ly1
1Department of Veterinary & Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Twin Cities, MN, USA.
Abstract:
Animal models that can replicate clinical and pathologic features of severe human coronavirus infections have been instrumental in the development of novel vaccines and therapeutics. The goal of this review is to summarize our current understanding of the pathogenesis of coronavirus disease 2019 (COVID-19) and the pathologic features that can be observed in several currently available animal models. Knowledge gained from studying these animal models of SARS-CoV-2 infection can help inform appropriate model selection for disease modelling as well as for vaccine and therapeutic developments.
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