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KINtaro: protein kinase-like database.

Bartosz Baranowski1, Marianna Krysińska2, Marcin Gradowski3

  • 1Laboratory of Plant Pathogenesis, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland.

BMC Research Notes
|February 16, 2024
PubMed
Summary
This summary is machine-generated.

The KINtaro database consolidates information on Protein Kinase-like (PKL) protein families, including novel ones. This resource aids researchers in understanding PKL proteins

Keywords:
HMMPhosphorylationPhosphotransferaseProtein kinasePseudokinaseStructure prediction

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Area of Science:

  • Biochemistry
  • Structural Biology
  • Bioinformatics

Background:

  • Protein Kinase-like (PKL) proteins share a common 3D fold and exhibit diverse enzymatic activities beyond phosphorylation.
  • PKL proteins are crucial in biological processes, including pathogen survival and human diseases like cancer and neurological disorders.
  • The expanding superfamily of PKL proteins necessitates continuous information gathering.

Purpose of the Study:

  • To establish a centralized resource for collecting and disseminating information on PKL protein families.
  • To provide comprehensive data on PKL families, including those not currently recognized in established databases.

Main Methods:

  • Development of the KINtaro database (http://bioinfo.sggw.edu.pl/kintaro/).
  • Integration of protein sequence data with extensive annotations for over 70 PKL families.
  • Inclusion of 32 novel PKL families absent from existing domain databases.

Main Results:

  • KINtaro offers a searchable platform for PKL protein information.
  • The database provides access to family descriptions, sequences, alignments, HMM models, and 3D structures.
  • Annotated experimental structures and sequence logos with catalytic residues are available.

Conclusions:

  • KINtaro serves as a valuable resource for researchers studying the diverse PKL protein superfamily.
  • The database facilitates the exploration of PKL protein functions and evolutionary relationships.
  • KINtaro supports ongoing research into PKL proteins' roles in health and disease.