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Updated: Jul 2, 2025

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Satiety: a gut-brain-relationship.

Ghinwa M Barakat1, Wiam Ramadan2,3, Ghaith Assi4

  • 1Biological and Chemical Sciences Department, School of Arts and Sciences, Lebanese International University, Beirut, Lebanon. ghinwa.barakat@liu.edu.lb.

The Journal of Physiological Sciences : JPS
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Summary
This summary is machine-generated.

Glucagon-like peptide-1 (GLP-1) and gut microbiome interactions influence satiety. This review explores how GLP-1, gut microbes, and neurotransmitters collectively regulate body weight homeostasis.

Keywords:
GLP-1MicrobiotaNeuroscienceNeurotransmittersSatiety

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Area of Science:

  • Neuroendocrinology
  • Gastrointestinal Physiology
  • Microbiome Research

Background:

  • Hormonal regulation of hunger and satiety involves complex hypothalamic pathways.
  • Enteroendocrine cells (EECs) in the GI tract release satiety signals like GLP-1.
  • Gut microbiome and neurotransmitters are increasingly recognized as factors influencing satiety.

Purpose of the Study:

  • To review the multifaceted roles of GLP-1 and its agonists in satiety.
  • To examine the influence of gut microbiota on satiety regulation.
  • To discuss the interplay between neurotransmitters, gut microbiome, and GLP-1 in maintaining energy homeostasis.

Main Methods:

  • Literature review synthesizing current research on satiety mechanisms.
  • Analysis of studies investigating GLP-1 hormone and its receptor agonists.
  • Exploration of research on the gut microbiome's impact on central and peripheral satiety signals.

Main Results:

  • GLP-1 and its agonists show significant potential for weight reduction by modulating satiety.
  • Gut microbiota composition is linked to alterations in satiety signaling pathways.
  • Neurotransmitter systems interact with gut-derived signals to regulate food intake.

Conclusions:

  • GLP-1, gut microbiome, and neurotransmitters are key interconnected regulators of satiety.
  • Understanding these interactions is crucial for developing novel therapeutic strategies for obesity and metabolic disorders.
  • Further research is warranted to elucidate the precise mechanisms governing satiety homeostasis.