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Studying Food Reward and Motivation in Humans
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Satiety: a gut-brain-relationship.

Ghinwa M Barakat1, Wiam Ramadan2, Ghaith Assi3

  • 1Biological and Chemical Sciences Department, School of Arts and Sciences, Lebanese International University, Beirut, Lebanon.

The Journal of Physiological Sciences : JPS
|January 22, 2025
PubMed
Summary
This summary is machine-generated.

Glucagon-like peptide-1 (GLP-1) and gut microbiome influence satiety. This review explores how GLP-1 agonists, gut bacteria, and neurotransmitters interact to regulate appetite and body weight homeostasis.

Keywords:
GLP-1MicrobiotaNeuroscienceNeurotransmittersSatiety

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Area of Science:

  • Neuroscience
  • Endocrinology
  • Microbiology

Background:

  • Hormones regulate hypothalamus functions controlling hunger and satiety.
  • Enteroendocrine cells (EECs) in the GI tract release satiety signals like GLP-1.
  • Gut microbiome and neurotransmitters also impact satiety regulation.

Purpose of the Study:

  • To review the roles of GLP-1, gut microbiome, and neurotransmitters in satiety.
  • To explore the interconnectedness of these factors in maintaining energy homeostasis.
  • To highlight GLP-1 agonists as potential weight reduction strategies.

Main Methods:

  • Literature review of hormonal, neural, and microbial pathways.
  • Analysis of signaling mechanisms in satiety regulation.
  • Synthesis of current evidence on appetite control.

Main Results:

  • GLP-1 and its agonists are key players in satiety and weight management.
  • Gut microbiota composition influences peripheral and central satiety signals.
  • Neurotransmitters play a crucial role in the neural control of appetite.

Conclusions:

  • Satiety is a complex process involving interactions between GLP-1, gut microbiota, and neurotransmitters.
  • Understanding these interactions is vital for managing body weight.
  • Targeting these pathways offers promising therapeutic avenues for obesity.