[Abortion in the 2d trimester using carboprost tromethamine]

Area of Science:

• Obstetrics and Gynecology
• Reproductive Medicine
• Pharmacology

Context:

• Second-trimester legal abortions present unique clinical challenges.
• Evaluating pharmacological agents for safe and effective pregnancy termination is crucial.
• Prostin 15-M (Upjohn) was investigated for its application in inducing abortions.

Purpose:

• To evaluate the efficacy and safety of Prostin 15-M using a "monotone rhythm and doses" protocol for second-trimester legal abortions.
• To analyze outcomes in different patient age groups (adolescent, adult, advanced maternal age).
• To compare this method with previously used abortion induction techniques.

Summary:

• A study involving 470 patients undergoing second-trimester abortions utilized Prostin 15-M.
• Outcomes were analyzed across three age groups, with varying indications for abortion.
• The method demonstrated a low complication rate (1.06%), with no reported deaths.

Impact:

• Prostin 15-M application proved to be a simple, efficacious, and clinically suitable method for second-trimester abortions.
• The study highlights its cost-effectiveness regarding treatment and hospitalization.
• The findings support Prostin 15-M as a viable option with advantages over alternative methods.