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Related Concept Videos

Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Hypersensitivities01:30

Hypersensitivities

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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
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Skin Diseases and Disorders01:23

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
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Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
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Related Experiment Video

Updated: Jul 2, 2025

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
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Canine Atopic Dermatitis: Prevalence, Impact, and Management Strategies.

Yvonne Drechsler1, Charli Dong2, David E Clark1

  • 1College of Veterinary Medicine, Western University of Health Sciences, Pomona, CA, USA.

Veterinary Medicine (Auckland, N.Z.)
|February 19, 2024
PubMed
Summary

Canine atopic dermatitis (AD) is a complex allergic skin disease with rising prevalence. Current treatments focus on managing symptoms like itching and inflammation, as a cure is unavailable.

Keywords:
alarminsimmune therapiesimmunopathologypruritussystemic therapiestopical therapies

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Area of Science:

  • Veterinary Dermatology
  • Immunology
  • Allergology

Background:

  • Atopic dermatitis (AD) is a prevalent, pruritic allergic skin condition affecting dogs globally.
  • Its pathogenesis is complex, involving genetic, immune, and environmental factors, including barrier dysfunction and microbiome alterations.
  • Canine AD (CAD) prevalence is increasing, with no definitive cure currently available.

Purpose of the Study:

  • To review the prevalence, impact, and immunological complexities of canine atopic dermatitis (CAD).
  • To discuss current management strategies for CAD, focusing on a multimodal approach.
  • To highlight the need for comprehensive treatment plans addressing diverse clinical signs.

Main Methods:

  • Literature review of existing data on canine atopic dermatitis.
  • Analysis of immunological interactions and contributing factors in AD pathogenesis.
  • Synthesis of information on current therapeutic interventions and management protocols.

Main Results:

  • Canine AD is a multifactorial disease with complex immunological underpinnings.
  • Effective management requires a multifaceted approach targeting pruritus, inflammation, infections, and barrier repair.
  • No cure exists, necessitating ongoing management strategies.

Conclusions:

  • Canine AD management necessitates a comprehensive, multimodal strategy tailored to individual patient needs.
  • Understanding the complex immunology is crucial for developing effective treatment plans.
  • Ongoing research is vital for improving the quality of life for dogs with CAD.