Bioactive 5/5/5/6 Four-Ring System Iridoids from Plumeria alba L
Xin Zhou1,2, Xin-Bin Meng1,2, Xue-Ming Zhou1,2
1Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education Hainan Normal University, Haikou, Hainan, 571158, China.
Abstract:
Two rare 5/5/5/6 four-ring system iridoids, allamancins A and B (1 and 2) together with one known biogenetically related iridoid derivative, 3-O-methyallamancin (3) were isolated from the flowers of Plumeria alba L. The structures of these iridoid derivatives were determined by comprehensive spectroscopic analyses. The absolute configuration of 1 was confirmed by X-ray crystallographic analysis. The inhibitory activities of compounds 1-3 against nitric oxide (NO) production induced and three cancer cell lines were evaluated in vitro. Compounds 1 and 3 showed inhibitory activities on NO production with IC50 values of 18.3±0.12 and 22.1±0.14 μM, respectively. Compounds 1-3 showed moderate inhibitory activities against cancer cell lines of A549, Hela and MCF-7.
More Related Videos
07:59A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
11:44Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B
Published on: January 19, 2022
Related Concept Videos
Cell Signaling in Plants
Five-Membered Heterocyclic Aromatic Compounds: Overview
Frost Circles for Different Conjugated Systems
ortho–para-Directing Activators: –CH3, –OH, –⁠NH2, –OCH3
UV–Vis Spectroscopy: Woodward–Fieser Rules
