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Establishing Fungal Entomopathogens as Endophytes: Towards Endophytic Biological Control
Published on: April 11, 2013
Two new polyketides from the mangrove endophytic fungus Penicillium sp. FDZ-018-102
Enkhchimeg Chuluunbaatar1,2, Mei-Zhu Wu1,2, Xin-Ming Song1,2
1Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University, Haikou, Hainan, China.
Abstract:
Two new polyketides polyketiliums A and B (1 and 2), together with ten known polyketides (3-12) were isolated from the mangrove endophytic fungus Penicillium sp. FDZ-018-102. Their chemical structures were elucidated by spectroscopic methods. The absolute configurations of polyketilium B (2) was determined by electronic circular dichroism (ECD) calculations. All compounds were evaluated for their antifungal and antibacterial activities. The antifungal activity of compound 11 against Fusarium oxysporum f. sp. cubense was notable, with an EC50 value of 18.12 µg/mL, surpassing the efficacy of captan (EC50: 49.16 µg/mL) by more than twofold. Compound 11 showed equal MIC values of 32 μg/mL against both Staphylococcus epidermidis and Bacillus cereus, while compound 12 exhibited MIC values of 16 and 32 μg/mL, respectively.
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