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Pharmacogenetic considerations in therapy with novel antiplatelet and anticoagulant agents

Anthony Yazbeck1, Reem Akika2, Zainab Awada2

  • 1Faculty of Medicine, American University of Beirut.

Pharmacogenetics and Genomics
|February 19, 2024
PubMed

Insights

Genetic variations significantly impact how individuals respond to antiplatelet and anticoagulant drugs, influencing treatment effectiveness and safety in cardiovascular medicine. This review highlights key pharmacogenetic findings for novel agents.

Area of Science:

  • Pharmacology
  • Genetics
  • Cardiovascular Medicine

Background:

  • Antiplatelets and anticoagulants are crucial for preventing and treating thrombosis but exhibit significant inter-individual variability in response.
  • Pharmacogenetic studies have identified genetic associations influencing the efficacy and safety of these medications.

Approach:

  • This review systematically searched Medline (2009-2023) and PharmGKB for evidence on pharmacogenetics of antiplatelets and anticoagulants.
  • Focus is placed on novel agents, excluding aspirin, warfarin, and heparins, to provide current insights.

Key Points:

  • Polymorphisms in candidate genes strongly correlate with the pharmacokinetics, pharmacodynamics, and clinical outcomes of clopidogrel and warfarin.
  • Emerging data on novel antiplatelets and anticoagulants are reviewed, emphasizing the level of evidence for genetic associations.

Conclusions:

  • Pharmacogenetics plays a vital role in personalizing antiplatelet and anticoagulant therapy.
  • Understanding genetic influences is essential for optimizing treatment strategies and improving patient outcomes in cardiovascular medicine.

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